Methods for Improved Flexural Mechanical Properties of 3D-Plotted PCL-Based Scaffolds for Heart Valve Tissue Engineering

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RAGAERT, Kim ;DE SOMER, Filip ;VAN DE VELDE, Stieven ;DEGRIECK, Joris ;CARDON, Ludwig .
Methods for Improved Flexural Mechanical Properties of 3D-Plotted PCL-Based Scaffolds for Heart Valve Tissue Engineering. 
Strojniški vestnik - Journal of Mechanical Engineering, [S.l.], v. 59, n.11, p. 669-676, june 2018. 
ISSN 0039-2480.
Available at: <https://www.sv-jme.eu/sl/article/methods-for-improved-flexural-mechanical-properties-of-3d-plotted-pcl-based-scaffolds-for-heart-valve-tissue-engineering/>. Date accessed: 18 jan. 2020. 
doi:http://dx.doi.org/10.5545/sv-jme.2013.1003.
Ragaert, K., De Somer, F., Van de Velde, S., Degrieck, J., & Cardon, L.
(2013).
Methods for Improved Flexural Mechanical Properties of 3D-Plotted PCL-Based Scaffolds for Heart Valve Tissue Engineering.
Strojniški vestnik - Journal of Mechanical Engineering, 59(11), 669-676.
doi:http://dx.doi.org/10.5545/sv-jme.2013.1003
@article{sv-jmesv-jme.2013.1003,
	author = {Kim  Ragaert and Filip  De Somer and Stieven  Van de Velde and Joris  Degrieck and Ludwig  Cardon},
	title = {Methods for Improved Flexural Mechanical Properties of 3D-Plotted PCL-Based Scaffolds for Heart Valve Tissue Engineering},
	journal = {Strojniški vestnik - Journal of Mechanical Engineering},
	volume = {59},
	number = {11},
	year = {2013},
	keywords = {scaffolds; mechanical properties; flexure; heart valves; tissue engineering; 3D plotting},
	abstract = {While porous poly-ε-caprolactone (PCL) scaffolds can be manufactured through 3D plotting with high regularity and reproducibility, it has been a challenge in previous research to mimic the highly flexible behaviour of the natural valve leaflets. In this study, an investigation is made of two separate approaches for the improved flexibility of 3D plotted PCL scaffolds for heart valve leaflets. Firstly, the scaffold geometry is radically altered towards a very open woven-like structure by adequately adapting the processing parameters during 3D plotting. Secondly, the base material itself is altered by blending a fraction of low-molecular weight poly-ethylene-oxide (PEO) into the PCL polymer. The scaffolds are 3D plotted for both series and their flexibility is evaluated in a uni-axial indentation experiment. The results are compared to those of the natural valve tissue and it is found that both approaches result in the desired reduction of the stiffness of the scaffold.},
	issn = {0039-2480},	pages = {669-676},	doi = {10.5545/sv-jme.2013.1003},
	url = {https://www.sv-jme.eu/sl/article/methods-for-improved-flexural-mechanical-properties-of-3d-plotted-pcl-based-scaffolds-for-heart-valve-tissue-engineering/}
}
Ragaert, K.,De Somer, F.,Van de Velde, S.,Degrieck, J.,Cardon, L.
2013 June 59. Methods for Improved Flexural Mechanical Properties of 3D-Plotted PCL-Based Scaffolds for Heart Valve Tissue Engineering. Strojniški vestnik - Journal of Mechanical Engineering. [Online] 59:11
%A Ragaert, Kim 
%A De Somer, Filip 
%A Van de Velde, Stieven 
%A Degrieck, Joris 
%A Cardon, Ludwig 
%D 2013
%T Methods for Improved Flexural Mechanical Properties of 3D-Plotted PCL-Based Scaffolds for Heart Valve Tissue Engineering
%B 2013
%9 scaffolds; mechanical properties; flexure; heart valves; tissue engineering; 3D plotting
%! Methods for Improved Flexural Mechanical Properties of 3D-Plotted PCL-Based Scaffolds for Heart Valve Tissue Engineering
%K scaffolds; mechanical properties; flexure; heart valves; tissue engineering; 3D plotting
%X While porous poly-ε-caprolactone (PCL) scaffolds can be manufactured through 3D plotting with high regularity and reproducibility, it has been a challenge in previous research to mimic the highly flexible behaviour of the natural valve leaflets. In this study, an investigation is made of two separate approaches for the improved flexibility of 3D plotted PCL scaffolds for heart valve leaflets. Firstly, the scaffold geometry is radically altered towards a very open woven-like structure by adequately adapting the processing parameters during 3D plotting. Secondly, the base material itself is altered by blending a fraction of low-molecular weight poly-ethylene-oxide (PEO) into the PCL polymer. The scaffolds are 3D plotted for both series and their flexibility is evaluated in a uni-axial indentation experiment. The results are compared to those of the natural valve tissue and it is found that both approaches result in the desired reduction of the stiffness of the scaffold.
%U https://www.sv-jme.eu/sl/article/methods-for-improved-flexural-mechanical-properties-of-3d-plotted-pcl-based-scaffolds-for-heart-valve-tissue-engineering/
%0 Journal Article
%R 10.5545/sv-jme.2013.1003
%& 669
%P 8
%J Strojniški vestnik - Journal of Mechanical Engineering
%V 59
%N 11
%@ 0039-2480
%8 2018-06-28
%7 2018-06-28
Ragaert, Kim, Filip  De Somer, Stieven  Van de Velde, Joris  Degrieck, & Ludwig  Cardon.
"Methods for Improved Flexural Mechanical Properties of 3D-Plotted PCL-Based Scaffolds for Heart Valve Tissue Engineering." Strojniški vestnik - Journal of Mechanical Engineering [Online], 59.11 (2013): 669-676. Web.  18 Jan. 2020
TY  - JOUR
AU  - Ragaert, Kim 
AU  - De Somer, Filip 
AU  - Van de Velde, Stieven 
AU  - Degrieck, Joris 
AU  - Cardon, Ludwig 
PY  - 2013
TI  - Methods for Improved Flexural Mechanical Properties of 3D-Plotted PCL-Based Scaffolds for Heart Valve Tissue Engineering
JF  - Strojniški vestnik - Journal of Mechanical Engineering
DO  - 10.5545/sv-jme.2013.1003
KW  - scaffolds; mechanical properties; flexure; heart valves; tissue engineering; 3D plotting
N2  - While porous poly-ε-caprolactone (PCL) scaffolds can be manufactured through 3D plotting with high regularity and reproducibility, it has been a challenge in previous research to mimic the highly flexible behaviour of the natural valve leaflets. In this study, an investigation is made of two separate approaches for the improved flexibility of 3D plotted PCL scaffolds for heart valve leaflets. Firstly, the scaffold geometry is radically altered towards a very open woven-like structure by adequately adapting the processing parameters during 3D plotting. Secondly, the base material itself is altered by blending a fraction of low-molecular weight poly-ethylene-oxide (PEO) into the PCL polymer. The scaffolds are 3D plotted for both series and their flexibility is evaluated in a uni-axial indentation experiment. The results are compared to those of the natural valve tissue and it is found that both approaches result in the desired reduction of the stiffness of the scaffold.
UR  - https://www.sv-jme.eu/sl/article/methods-for-improved-flexural-mechanical-properties-of-3d-plotted-pcl-based-scaffolds-for-heart-valve-tissue-engineering/
@article{{sv-jme}{sv-jme.2013.1003},
	author = {Ragaert, K., De Somer, F., Van de Velde, S., Degrieck, J., Cardon, L.},
	title = {Methods for Improved Flexural Mechanical Properties of 3D-Plotted PCL-Based Scaffolds for Heart Valve Tissue Engineering},
	journal = {Strojniški vestnik - Journal of Mechanical Engineering},
	volume = {59},
	number = {11},
	year = {2013},
	doi = {10.5545/sv-jme.2013.1003},
	url = {https://www.sv-jme.eu/sl/article/methods-for-improved-flexural-mechanical-properties-of-3d-plotted-pcl-based-scaffolds-for-heart-valve-tissue-engineering/}
}
TY  - JOUR
AU  - Ragaert, Kim 
AU  - De Somer, Filip 
AU  - Van de Velde, Stieven 
AU  - Degrieck, Joris 
AU  - Cardon, Ludwig 
PY  - 2018/06/28
TI  - Methods for Improved Flexural Mechanical Properties of 3D-Plotted PCL-Based Scaffolds for Heart Valve Tissue Engineering
JF  - Strojniški vestnik - Journal of Mechanical Engineering; Vol 59, No 11 (2013): Strojniški vestnik - Journal of Mechanical Engineering
DO  - 10.5545/sv-jme.2013.1003
KW  - scaffolds, mechanical properties, flexure, heart valves, tissue engineering, 3D plotting
N2  - While porous poly-ε-caprolactone (PCL) scaffolds can be manufactured through 3D plotting with high regularity and reproducibility, it has been a challenge in previous research to mimic the highly flexible behaviour of the natural valve leaflets. In this study, an investigation is made of two separate approaches for the improved flexibility of 3D plotted PCL scaffolds for heart valve leaflets. Firstly, the scaffold geometry is radically altered towards a very open woven-like structure by adequately adapting the processing parameters during 3D plotting. Secondly, the base material itself is altered by blending a fraction of low-molecular weight poly-ethylene-oxide (PEO) into the PCL polymer. The scaffolds are 3D plotted for both series and their flexibility is evaluated in a uni-axial indentation experiment. The results are compared to those of the natural valve tissue and it is found that both approaches result in the desired reduction of the stiffness of the scaffold.
UR  - https://www.sv-jme.eu/sl/article/methods-for-improved-flexural-mechanical-properties-of-3d-plotted-pcl-based-scaffolds-for-heart-valve-tissue-engineering/
Ragaert, Kim, De Somer, Filip, Van de Velde, Stieven, Degrieck, Joris, AND Cardon, Ludwig.
"Methods for Improved Flexural Mechanical Properties of 3D-Plotted PCL-Based Scaffolds for Heart Valve Tissue Engineering" Strojniški vestnik - Journal of Mechanical Engineering [Online], Volume 59 Number 11 (28 June 2018)

Avtorji

Inštitucije

  • University College Ghent, CPMT, Associated Faculty of Applied Engineering Sciences, Belgium 1
  • University Hospital Ghent, Heart Centre, Ghent, Belgium 2
  • Ghent University, Faculty of Engineering and Architecture, Department of Materials Science and Engineering, Belgium 3

Informacije o papirju

Strojniški vestnik - Journal of Mechanical Engineering 59(2013)11, 669-676

https://doi.org/10.5545/sv-jme.2013.1003

While porous poly-ε-caprolactone (PCL) scaffolds can be manufactured through 3D plotting with high regularity and reproducibility, it has been a challenge in previous research to mimic the highly flexible behaviour of the natural valve leaflets. In this study, an investigation is made of two separate approaches for the improved flexibility of 3D plotted PCL scaffolds for heart valve leaflets. Firstly, the scaffold geometry is radically altered towards a very open woven-like structure by adequately adapting the processing parameters during 3D plotting. Secondly, the base material itself is altered by blending a fraction of low-molecular weight poly-ethylene-oxide (PEO) into the PCL polymer. The scaffolds are 3D plotted for both series and their flexibility is evaluated in a uni-axial indentation experiment. The results are compared to those of the natural valve tissue and it is found that both approaches result in the desired reduction of the stiffness of the scaffold.

scaffolds; mechanical properties; flexure; heart valves; tissue engineering; 3D plotting